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KMID : 0043319950180060396
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Archives of Pharmacal Research
1995 Volume.18 No. 6 p.396 ~ p.401
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Antitumor Activity of Pedunculagin, one of the Ellagitannin
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Chang Jee-Hun
Cho Jang-Hyun
Kim Ha-Hyung
Lee Kwang-Pyo
Lee Min-Won
Han Seong -Sun
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Abstract
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As a part of trials to develop the antitumor agent from tannins isolated from plants, the antitumor activity of peduculagin, an ellagitannin, isolated from Alnus hirsuta var. microphylla was examined in vitro and in vivo. In vitro, the cytotoxicity was determined by 0.4% typanblue dye exclusion method. peduculagin showed the dose-dependent cytotoxicity against human chronic myelogenous leukemia (K-562), human promyelocytic leukemia (HL-60), mouse lymphoid neoplasm (P388), mouse lymphocytic leukemia (L1210) and mouse sarcoma 180(S180) cell lines. of each cell line were 5.30, 0.92, 2.78, 9.35 and respectively. The most sensitive cell line was HL-60. In vivo, pedunculagin was administered to ICR mouse with the doses of 50 and intraperitoneally once at 20 days before S180 inoculation. peduculagin showed the antitumor activity and its T/C ratio (%) was 120.82% in the group of both concentrations.
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KEYWORD
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Pedunculagin, Antitumor activity, Ellagitnannin, T/C ratio
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